1386 PLASMA PROSTAGLANDIN RESPONSE TO INDOMETHACIN THERAPY FOR PATENT DUCTUS ARTERIOSUS IN PREMATURE INFANTS
نویسندگان
چکیده
منابع مشابه
Echocardiographic flow pattern of patent ductus arteriosus: a guide to indomethacin treatment in premature infants.
AIM To compare the efficacy and safety of an indomethacin treatment strategy based on serial echocardiographic measurement of patent ductus arteriosus (PDA) flow pattern with a standard protocol. METHODS Neonates weighing less than 1500 g at birth, who required respiratory support, and who had developed symptomatic PDA, were studied. PDA was confirmed in all infants using colour Doppler echoc...
متن کاملTolerance of intravenous indomethacin treatment for premature infants with patent ductus arteriosus.
stable or partial response, suggesting that, in addition to causing sclerosis of bone, APD may have an antitumour effect. Factors released from tumours stimulate osteoblastic activity3 and osteolysis mediated by osteoclasts.4 APD is a potent inhibitor of osteoclast function, and such inhibition combined with the osteoblastic factors produced by tumour cells may explain the bony sclerosis seen i...
متن کاملPersistent Doppler flow predicts lack of response to multiple courses of indomethacin in premature infants with recurrent patent ductus arteriosus.
OBJECTIVE Although indomethacin produces ductus arteriosus constriction in extremely premature newborns, a recurrent symptomatic patent ductus arteriosus (PDA) frequently develops after the initial course of indomethacin. Currently, there is little information available to determine the effectiveness of a second course of indomethacin in producing permanent ductus closure. The objective of this...
متن کاملIndomethacin treatment in small versus large premature infants with ductus arteriosus. Comparison of plasma indomethacin concentration and clinical response.
An analysis of clinical response and plasma indomethacin concentration was performed on 10 small (less than or equal to 1000 g) and 12 large (greater than 1000 g) premature infants who had symptomatic ductus arteriosus and required intravenous indomethacin therapy (0.3 mg/kg per day). The postnatal age, daily fluid intake, and cardiopulmonary status of the two groups at time of study were compa...
متن کاملPoor response to oral indomethacin therapy for persistent ductus arteriosus in very low birthweight infants.
Administration of oral indomethacin to treat cardiorespiratory failure in 7 low birthweight infants, after failure of conventional therapy, produced an improvement in only 2 infants. These infants had a higher birthweight than the group as a whole. Surgical ligation, rather than oral indomethacin, may be the treatment of choice for persistent ductus arteriosus in very low birthweight infants.
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1985
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198504000-01410